Localization, analysis and evolution of transposed human immunoglobulin V" genes
نویسندگان
چکیده
The localization of V", gene regions to chromosome 2, on which the K locus is located, and to other chromosomes is described. The V", genes that have been transposed to other chromosomes are called orphons. The finding of two new V", genes on chromosome 22 is reported. A V", 11 gene of this region and two V", I genes of the Chr 1 and the cos 118 regions were sequenced. The two V", I orphon sequences and two others that had been determined previously were 97.5% identical, indicating that they may have evolved from a common ancestor by amplification. A model of the evolution of the human V", orphons is discussed.
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